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About This Role
POSITION SUMMARY:
Natera is seeking a Senior Machine Learning Scientist to join our AI team, an advanced R\&D and core AI innovation team bridging the gap between molecular discovery and clinical execution. Leveraging a proprietary data moat of over 250,000 oncology patients profiled with longitudinal ctDNA, WES/WGS, digital pathology, and EMR data, you will design and deploy production\-grade autonomous AI agents and multi\-modal foundation models. Your mission is to architect systems capable of multi\-step biological reasoning, converting complex multi\-omic datasets into verifiable clinical insights that accelerate biomarker and therapeutic discovery. You will lead the next evolution of our Agentic AI platform, designing autonomous systems capable of reasoning through the complexities of cancer biology, orchestrating proprietary foundation models, and simulating virtual patient trajectories.
PRIMARY RESPONSIBILITIES
- Lead the technical design and deployment of multi\-agent systems capable of autonomous hypothesis generation and tool use, including genomic variant calling, LLM fine\-tuning, and clinical trial matching pipelines
- Incorporate and advance Natera’s transformer\-based foundation model by integrating DNA, RNA, and H\&E imaging modalities for multi\-step biological reasoning and tool use
- Implement advanced LLM reasoning frameworks, such as ReAct and Chain\-of\-Thought, alongside reinforcement fine\-tuning (RFT) to ensure agents provide accurate, explainable clinical rationales
- Architect systems that autonomously translate complex, multi\-modal data into diagnostic and therapeutic insights with human\-verifiable reasoning and tracing
- Own the technical strategy and product roadmap for agentic workflows across the Biopharma Solutions and Therapeutics Discovery division, converting complex clinical challenges into scalable AI systems
- Establish production\-grade machine learning engineering standards and reproducible architectures across the AI team to ensure absolute model transparency and scientific auditability
- Drive cross\-functional alignment and technical consensus by defending agentic architectures and biological reasoning frameworks in rigorous peer reviews
QUALIFICATIONS:
- PhD or Master's degree in Computer Science, Bioinformatics, Statistics, or a related quantitative field
- 8 or more years of experience in AI research or engineering, with a proven track record of moving multi\-agent orchestration architectures or large\-scale language model workflows from prototype to production
- Deep experience with agentic frameworks, such as LangChain or Claude Agent SDK, retrieval\-augmented generation (RAG), and validation frameworks for autonomous AI agents
- Strong understanding of cancer genomics (WES/WTS), mutational signatures, and structure\-activity relationships
- Advanced production\-level development experience using PyTorch and experience with distributed training on large GPU clusters, including NVIDIA H100s
KNOWLEDGE, SKILLS, AND ABILITIES:
- Ability to operate with absolute ownership to close operational gaps and independently drive architectural deployment
- Data\-driven decision\-making focused on empirical model performance and clinical validity
- Technical leadership capability to define long\-term AI engineering roadmaps
- Rigor in code architecture, reproducibility, and production\-grade software engineering practices
- Comfort with high intellectual friction and the ability to defend scientific and engineering choices under rigorous internal peer review
- Focus on translating machine learning outcomes directly into patient\-centric clinical utility
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years \& depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$169,800 \- $212,300 USD
Compensation \& Total Rewards
This range reflects a good\-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.
This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:
- Annual performance incentive bonus
- Long\-term equity awards
- Comprehensive health benefits (medical, dental, vision)
- 401(k) with company match
- Generous paid time off and company holidays
- Additional wellness and work\-life benefits
Compensation Range
$160,335\.12 \- $200,418\.90 USD
OUR OPPORTUNITY
Natera™ is a global leader in cell\-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world\-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits \- Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
*If you are based in California, we encourage you to read this important information for California residents.*
Link: https://www.natera.com/notice\-of\-data\-collection\-california\-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
Salary Context
This $160K-$200K range is below the median for AI/ML Engineer roles in our dataset (median: $181K across 1996 roles with salary data).
View full AI/ML Engineer salary data →Role Details
About This Role
AI/ML Engineers build and deploy machine learning models in production. They work across the full ML lifecycle: data pipelines, model training, evaluation, and serving infrastructure. The role has evolved significantly over the past two years. Where ML Engineers once spent most of their time on model architecture, the job now tilts heavily toward inference optimization, cost management, and integrating LLM capabilities into existing systems. Companies want engineers who can ship production systems, and the experimenter-only role is fading fast.
Day-to-day, you're writing training pipelines, debugging data quality issues, setting up evaluation frameworks, and figuring out why your model performs differently in staging than it did on your dev set. The best ML engineers are obsessive about reproducibility and measurement. They instrument everything. They know that a model is only as good as the data feeding it and the infrastructure serving it.
Across the 3,824 AI roles we're tracking, AI/ML Engineer positions make up 71% of the market. At Natera, this role fits into their broader AI and engineering organization.
Demand for AI/ML Engineers has been strong and consistent. Unlike some AI roles that spike with hype cycles, ML engineering is a foundational need. Every company deploying AI models needs people who can keep them running, and the gap between research prototypes and production systems keeps growing.
What the Work Looks Like
A typical week might include: debugging a data pipeline that's silently dropping 3% of training examples, running A/B tests on a new model version, writing documentation for a feature flag system that lets you roll back model deployments, and reviewing a junior engineer's PR for a new evaluation metric. Meetings tend to be cross-functional since ML touches product, engineering, and data teams.
Demand for AI/ML Engineers has been strong and consistent. Unlike some AI roles that spike with hype cycles, ML engineering is a foundational need. Every company deploying AI models needs people who can keep them running, and the gap between research prototypes and production systems keeps growing.
Skills Required
Python and PyTorch dominate the requirements. Most roles expect experience with cloud platforms (AWS, GCP, or Azure) and familiarity with ML frameworks like TensorFlow or JAX. RAG (Retrieval-Augmented Generation) has become a top-3 skill requirement as companies integrate LLMs into their products. Docker and Kubernetes show up in about a third of postings, reflecting the production focus of the role.
Beyond the core stack, employers increasingly want experience with experiment tracking tools (MLflow, Weights & Biases), feature stores, and vector databases. Fine-tuning experience is valuable but less common than you'd think from reading Twitter. Most production LLM work is RAG and prompt engineering, not fine-tuning. If you have both, you're in a strong position.
Companies that are serious about AI/ML hiring tend to post specific infrastructure details in the job description: the frameworks they use, their model serving stack, their data pipeline tools. Vague postings that just say 'ML experience required' without specifics are often companies that haven't figured out what they need yet.
Compensation Benchmarks
AI/ML Engineer roles pay a median of $178,940 based on 11,900 positions with disclosed compensation. Senior-level AI roles across all categories have a median of $227,400. Disclosed range: $160K to $200K.
Across all AI roles, the market median is $200,000. Top-quartile compensation starts at $253,000. The 90th percentile reaches $307,500. For comparison, the highest-paying categories include AI Engineering Manager ($293,500) and AI Safety ($274,200). By seniority level: Entry: $97,380; Mid: $160,000; Senior: $227,400; Director: $243,000; VP: $250,000.
Natera AI Hiring
Natera has 8 open AI roles right now. They're hiring across AI/ML Engineer, AI Software Engineer. Based in Remote, US. Compensation range: $132K - $233K.
Remote Work Context
Remote AI roles pay a median of $169,035 across 1,817 positions. About 16% of all AI roles offer remote work.
Career Path
Common paths into AI/ML Engineer roles include Data Scientist, Software Engineer, Research Engineer.
From here, career progression typically leads toward ML Architect, AI Engineering Manager, Principal ML Engineer.
The fastest path into ML engineering is through software engineering with a self-directed ML education. A CS degree helps, but production engineering skills matter more than academic credentials. Build something that works, deploy it, and measure it. That portfolio project is worth more than a Coursera certificate. For career growth, the fork comes around the senior level: go deep on technical complexity (staff/principal track) or move into managing ML teams.
What to Expect in Interviews
Expect system design questions around ML pipelines: how you'd build a training pipeline for a specific use case, handle data drift, or design A/B testing infrastructure for model deployments. Coding rounds typically involve Python, with emphasis on data manipulation (pandas, numpy) and algorithm implementation. Take-home assignments often ask you to build an end-to-end ML pipeline from raw data to deployed model.
When evaluating opportunities: Companies that are serious about AI/ML hiring tend to post specific infrastructure details in the job description: the frameworks they use, their model serving stack, their data pipeline tools. Vague postings that just say 'ML experience required' without specifics are often companies that haven't figured out what they need yet.
AI Hiring Overview
The AI job market has 3,824 open positions tracked in our dataset. By seniority: 119 entry-level, 1,813 mid-level, 1,472 senior, and 420 leadership roles (Director, VP, C-Level). Remote roles make up 16% of the market (613 positions). The remaining 3,187 roles require on-site or hybrid attendance.
The market median for AI roles is $200,000. Top-quartile compensation starts at $253,000. The 90th percentile reaches $307,500. Highest-paying categories: AI Engineering Manager ($293,500 median, 31 roles); AI Safety ($274,200 median, 51 roles); Research Engineer ($260,000 median, 401 roles).
Demand for AI/ML Engineers has been strong and consistent. Unlike some AI roles that spike with hype cycles, ML engineering is a foundational need. Every company deploying AI models needs people who can keep them running, and the gap between research prototypes and production systems keeps growing.
The AI Job Market Today
The AI job market spans 3,824 open positions across 15 role categories. The largest categories by volume: AI/ML Engineer (2,702), Data Scientist (281), AI Software Engineer (258). These three account for the majority of open positions, though smaller categories often have higher per-role compensation because of specialized skill requirements.
The seniority mix tells a story about where AI teams are in their maturity. Entry-level roles (119) are outnumbered by mid-level (1,813) and senior (1,472) positions, reflecting that most companies are past the 'build a team from scratch' phase and need experienced engineers who can ship production systems. Leadership roles (Director, VP, C-Level) total 420 positions, representing the bottleneck between technical execution and organizational strategy.
Remote work availability sits at 16% of all AI roles (613 positions), with 3,187 requiring on-site or hybrid attendance. The remote share has stabilized after the post-pandemic correction. Senior and specialized roles (Research Scientist, ML Architect) are more likely to be remote-eligible than entry-level positions, partly because experienced hires have more negotiating power and partly because these roles require less hands-on mentorship.
AI compensation is structured in clear tiers. The market median sits at $200,000. Top-quartile roles start at $253,000, and the 90th percentile reaches $307,500. These figures include base salary with disclosed compensation. Total compensation (including equity, bonuses, and sign-on) runs 20-40% higher at companies that offer those components.
Category matters for compensation. AI Engineering Manager roles lead at $293,500 median, while Prompt Engineer roles sit at $142,800. The spread between highest and lowest-paying categories reflects the premium on specialized technical skills versus broader analytical roles.
The most in-demand skills across all AI postings: Python (1,968 postings), Aws (1,203 postings), Azure (882 postings), Rag (877 postings), Gcp (735 postings), Prompt Engineering (587 postings), Pytorch (586 postings), Claude (554 postings). Python dominates, appearing in the vast majority of role descriptions regardless of category. Cloud platform experience (AWS, GCP, Azure) is the second most common requirement. The newer entrants to the top skills list (RAG, vector databases, LLM APIs) reflect the shift from traditional ML toward generative AI applications.
Frequently Asked Questions
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